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Article

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

The EMBO journal - 13 Oct 2004

Komander David, Fairservice Alison, Deak Maria, Kular Gursant S, Prescott Alan R, Peter Downes C, Safrany Stephen T, Alessi Dario R, van Aalten Daan M F

Abstract excerpt

3-phosphoinositide-dependent protein kinase-1 (PDK1) phosphorylates and activates many kinases belonging to the AGC subfamily. PDK1 possesses a C-terminal pleckstrin homology (PH) domain that interacts with PtdIns(3,4,5)P3/PtdIns(3,4)P2 and with lower affinity to PtdIns(4,5)P2. We describe the crystal structure of the PDK1 PH domain, in the absence and presence of PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4. The...

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Source

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Identifiers

PMID: 15457207
DOI: 10.1038/sj.emboj.7600379
PMCID: PMC524332

Genes

PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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