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Article

Molecular modeling studies of the Akt PH domain and its interaction with phosphoinositides.

Journal of medicinal chemistry - 15 Mar 2001

Rong S B, Hu Y, Enyedy I, Powis G, Meuillet E J, Wu X, Wang R, Wang S, Kozikowski A P

Abstract excerpt

The serine-threonine protein kinase Akt is a direct downstream target of phosphatidylinositol 3-kinase (PI3-K). The PI3-K-generated phospholipids regulate Akt activity via directly binding to the Akt PH domain. The binding of PI3-K-generated phospholipids is critical to the relocalization of Akt to the plasma membrane, which plays an important role in the process of Akt activation. Activation of the PI3-K/Akt...

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Identifiers

PMID: 11300871
DOI: 10.1021/jm000493i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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