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Article

CTLA-4: a negative regulator of autoimmune disease.

1 Aug 1996

Abstract excerpt

CTLA-4, a CD28 homologue expressed on activated T cells, binds with high affinity to the CD28 ligands, B7-1 (CD80) and B7-2 (CD86). This study was designed to examine the role of CTLA-4 in regulating autoimmune disease. Murine relapsing-remitting experimental autoimmune encephalomyelitis (R-EAE) is a demyelinating disease mediated by PLP139-151-specific CD4+ T cells in SJL/J mice. Anti-CTLA-4 mAbs (or their F(ab)...

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Identifiers

PMID: 8760834
DOI: 10.1084/jem.184.2.783

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CTLA-4: a negative regulator of autoimmune disease.PMID 8760834Read ↗

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