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Article

CD28-dependent differentiation into the effector/memory phenotype is essential for induction of arthritis in interleukin-1 receptor antagonist-deficient mice.

Arthritis and rheumatism - 1 Feb 2006

Kotani Motoko, Hirata Kazuya, Ogawa Shuhei, Habiro Katsuyoshi, Ishida Yasuo, Tanuma Seiichi, Horai Reiko, Iwakura Yoichiro, Kishimoto Hidehiro, Abe Ryo

Abstract excerpt

OBJECTIVE: Interleukin-1 receptor antagonist (IL-1Ra)-deficient mice on a BALB/c background spontaneously develop a chronic inflammatory polyarthropathy closely resembling that of rheumatoid arthritis in humans. To elucidate the role of CD28 costimulatory signals in the development of this disease, we studied IL-1Ra/CD28-double-deficient mice. METHODS: We crossed IL-1Ra-deficient mice with CD28-deficient mice and...

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Identifiers

PMID: 16453283
DOI: 10.1002/art.21769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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