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Article

Co-stimulatory modulation in rheumatoid arthritis: the role of (CTLA4-Ig) abatacept.

Autoimmunity reviews - 1 Oct 2008

Fiocco Ugo, Sfriso Paolo, Oliviero Francesca, Pagnin Elisa, Scagliori Elena, Campana Carla, Dainese Serena, Cozzi Luisella, Punzi Leonardo

Abstract excerpt

Associations between rheumatoid arthritis (RA) susceptibility and polymorphism in multiple immunoregulatory genes suggest a role of altered T cell function in the disease. The growing relevance of the oxidative stress in RA synovitis, which results in a number of T cell signalling abnormalities, is reinforced by the demonstration of a direct NO inducing activity through the shared epitope of the HLA class II...

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Topics

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Share to Abatacept
Share to B7-1 Antigen

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CTLA-4 Antigen

Share to Immune Tolerance

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Share to Molecular Mimicry

Share to Receptors, IgG

Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 18718877
DOI: 10.1016/j.autrev.2008.07.035

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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