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Article

Treatment of Murine Lupus with CTLA4Ig

26 Aug 1994

Abstract excerpt

The interaction of B7-related molecules on antigen-presenting cells with CD28 or CTLA-4 antigens on T cells provides a second signal for T cell activation. Selection inhibition of the B7-CD28 or B7-CTLA-4 interactions produces antigen-specific T cell unresponsiveness in vitro and suppresses immune function in vivo. To determine whether selective inhibition of the B7-CD28 or B7-CTLA-4 interactions could suppress...

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Identifiers

PMID: 7520604
DOI: 10.1126/science.7520604

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