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Article

Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris.

European journal of immunology - 1 Mar 2002

Tsunoda Kazuyuki, Ota Takayuki, Suzuki Harumi, Ohyama Manabu, Nagai Tetsuo, Nishikawa Takeji, Amagai Masayuki, Koyasu Shigeo

Abstract excerpt

Mechanisms of tolerance break against desmoglein 3 (Dsg3) in patients with pemphigus vulgaris (PV) producing pathogenic anti-Dsg3 IgG autoantibodies are unclear. In this study, using a novel PV mouse model involving Dsg3 knockout mice, we investigated the mechanisms leading to production of autoantibodies against Dsg3. Adoptive transfer of Dsg3(-/-) splenocytes immunized with recombinant mouse Dsg3 to Rag2(-/-)...

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Identifiers

PMID: 11857336
DOI: 10.1002/1521-4141(200203)32:3<627::AID-IMMU627>3.0.CO;2-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris.PMID 11857336Read ↗

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