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Autoantibody-Specific Signalling in Pemphigus

9 Aug 2021

Abstract excerpt

Pemphigus is a severe autoimmune disease impairing barrier functions of epidermis and mucosa. Autoantibodies primarily target the desmosomal adhesion molecules desmoglein (Dsg) 1 and Dsg 3 and induce loss of desmosomal adhesion. Strikingly, autoantibody profiles in pemphigus correlate with clinical phenotypes. Mucosal-dominant pemphigus vulgaris (PV) is characterised by autoantibodies (PV-IgG) against Dsg3...

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Identifiers

PMID: 34434944
DOI: 10.3389/fmed.2021.701809

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