Article
Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus.
The Journal of clinical investigation - 1 Mar 2000
Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T
Abstract excerpt
The development of experimental models of active autoimmune diseases can be difficult due to tolerance of autoantigens, but knockout mice, which fail to acquire tolerance to the defective gene product, provide a useful tool for this purpose. Using knockout mice lacking desmoglein 3 (Dsg3), the ta...
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