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Article

Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus.

The Journal of clinical investigation - 1 Mar 2000

Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T

Abstract excerpt

The development of experimental models of active autoimmune diseases can be difficult due to tolerance of autoantigens, but knockout mice, which fail to acquire tolerance to the defective gene product, provide a useful tool for this purpose. Using knockout mice lacking desmoglein 3 (Dsg3), the target antigen of pemphigus vulgaris (PV), we have generated an active disease model for this autoantibody-mediated...

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Identifiers

PMID: 10712434
DOI: 10.1172/JCI8748
PMCID: PMC292455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus.PMID 10712434Read ↗

Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris.Semantic proximity Read ↗

Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris.Semantic proximity Read ↗

A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice.Semantic proximity Read ↗

Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice.Semantic proximity Read ↗

Ultrastructural changes in mice actively producing antibodies to desmoglein 3 parallel those in patients with pemphigus vulgaris.Semantic proximity Read ↗

Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris.Semantic proximity Read ↗

Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions.Semantic proximity Read ↗

Mucosal pemphigus vulgaris anti-Dsg3 IgG is pathogenic to the oral mucosa of humanized Dsg3 mice.Semantic proximity Read ↗

Confirmation of a disease model of pemphigus vulgaris: characterization and correlation between disease parameters in 90 mice.Semantic proximity Read ↗

Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris.Semantic proximity Read ↗

Inhibition of immunoglobulin class-switching prevents pemphigus onset in desmoglein 3-specific B cell receptor knock-in mouseSemantic proximity Read ↗

Pemphigus mouse model as a tool to evaluate various immunosuppressive therapies.Semantic proximity Read ↗

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