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Putative azithromycin-resistance mutations in <i>Chlamydia trachomatis</i> are globally distributed but arose before azithromycin was discovered

2025-11-12

Abstract excerpt

Azithromycin is widely used to treat Chlamydia trachomatis infections, yet the extent of resistance to the drug across the species has not been addressed. We surveyed mutations and substitutions linked to putative azithromycin resistance across 1,354 high-quality C. trachomatis genomes. Mutations in the rpl V gene encoding three non-synonymous substitutions, compared to the canonical C. trachomatis reference s...

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Literature Corpus work
ed28ebf3-a1c4-53db-83a2-bd8c67cd2ed6
DOI
10.1101/2025.11.10.687758
Open publication

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Putative azithromycin-resistance mutations in <i>Chlamydia trachomatis</i> are globally distributed but arose before azithromycin was discoveredDOI 10.1101/2025.11.10.687758
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