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Local emergence and global evolution of Neisseria gonorrhoeae with high-level resistance to azithromycin.

Antimicrobial agents and chemotherapy - 5 Dec 2024

Melendez Johan H, Edwards Vonetta L, Muniz Tirado Adamaris, Hardick Justin, Mehta Aditya, Aluvathingal Jain, D'Mello Adonis, Gaydos Charlotte A, Manabe Yukari C, Tettelin Hervé

Abstract excerpt

Antimicrobial resistance in Neisseria gonorrhoeae (Ng) has severely reduced treatment options, including azithromycin (AZM), which had previously been recommended as dual therapy with ceftriaxone. This study characterizes the emergence of high-level resistance to AZM (HLR-AZM) Ng in Baltimore, Maryland, USA, and describes the global evolution of HLR-AZM Ng. Whole genome sequencing (WGS) of 30 Ng isolates with and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39445818
DOI: 10.1128/aac.00927-24
PMCID: PMC11619321

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