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Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the rat

2024-02-28

Abstract excerpt

<h4>ABSTRACT</h4> In opioid use disorder (OUD) patients, a decrease in brain grey matter volume (GMV) has been reported. It is unclear whether this is the consequence of prolonged exposure to opioids or is a predisposing causal factor in OUD development. To investigate this, we conducted a structural MRI longitudinal study in NIH Heterogeneous Stock rats exposed to heroin self-administration and age-matched naïve...

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Literature Corpus work
ed169f6f-099d-502b-82f2-a1d33665b412
DOI
10.1101/2024.02.26.582024
Open publication

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Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in the ratDOI 10.1101/2024.02.26.582024
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