Article
Cortical thickness abnormalities in cocaine addiction--a reflection of both drug use and a pre-existing disposition to drug abuse?
Neuron - 9 Oct 2008
Makris Nikos, Gasic Gregory P, Kennedy David N, Hodge Steven M, Kaiser Jonathan R, Lee Myung Joo, Kim Byoung Woo, Blood Anne J, Evins A Eden, Seidman Larry J, Iosifescu Dan V, Lee Sang, Baxter Claudia, Perlis Roy H, Smoller Jordan W, Fava Maurizio, Breiter Hans C
Abstract excerpt
The structural effects of cocaine on neural systems mediating cognition and motivation are not well known. By comparing the thickness of neocortical and paralimbic brain regions between cocaine-dependent and matched control subjects, we found that four of 18 a priori regions involved with executive regulation of reward and attention were significantly thinner in addicts. Correlations were significant between...
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