Article

Extracellular Matrix Abnormalities in the Hippocampus of Subjects with Substance Use Disorder

2023-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Contextual triggers are significant factors contributing to relapse in substance use disorders (SUD). Emerging evidence points to a critical role of extracellular matrix (ECM) molecules as mediators of reward memories. Chondroitin sulfate proteoglycans (CSPGs) are a subset of ECM molecules that form perineuronal nets (PNN) around inhibitory neurons. PNNs restrict synaptic connections and help mai...

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Literature Corpus work: 7637dae1-6fca-5685-9dfe-d788f7c06d2c
DOI: 10.1101/2023.09.07.23295222

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