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Leak current, even with gigaohm seals, can cause misinterpretation of stem-cell derived cardiomyocyte action potential recordings

2022-10-17

Abstract excerpt

Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have become an essential tool to study arrhythmia mechanisms. Much of the foundational work on these cells, and the computational models built from the resultant data, has overlooked the contribution of seal-leak current on the immature and heterogeneous phenotype that has come to define these cells. Here, we use in silico and in vitro studies...

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Literature Corpus work
ed0f000c-05c9-5574-8828-b5190144b9e5
DOI
10.1101/2022.10.13.511949
Open publication

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Leak current, even with gigaohm seals, can cause misinterpretation of stem-cell derived cardiomyocyte action potential recordingsDOI 10.1101/2022.10.13.511949
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