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Article

A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources.

The Journal of physiology - 1 Sept 2019

Kernik Divya C, Morotti Stefano, Wu HaoDi, Garg Priyanka, Duff Henry J, Kurokawa Junko, Jalife José, Wu Joseph C, Grandi Eleonora, Clancy Colleen E

Abstract excerpt

KEY POINTS: Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) capture patient-specific genotype-phenotype relationships, as well as cell-to-cell variability of cardiac electrical activity Computational modelling and simulation provide a high throughput approach to reconcile multiple datasets describing physiological variability, and also identify vulnerable parameter regimes We have developed a...

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Identifiers

PMID: 31278749
DOI: 10.1113/JP277724
PMCID: PMC6767694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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