Article

Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endodermal gene regulatory network

2020-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key transcriptional regulator of definitive endoderm development, and yet, its genomic targets remain largely uncharacterized. Here, using genomic approaches and epistasis experiments, we define the Sox17-governed endoder...

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Literature Corpus work: ed0cd0f3-bee4-5f12-8e3c-7fead97e831b
DOI: 10.1101/2020.02.19.956565

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