Article

Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumour fate

2019-05-20

Abstract excerpt

<h4>ABSTRACT</h4> Embryonal carcinomas (ECs) and seminomas are testicular germ cell tumours. ECs display expression of SOX2, while seminomas display expression of SOX17. In somatic differentiation, SOX17 drives endodermal cell fate. However, seminomas lack expression of endoderm markers, but show features of pluripotency. Here, we use ChIP-sequencing to report and compare the binding pattern of SOX17 in seminoma-...

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Literature Corpus work: bc5a2b56-3095-5152-90c4-3c90e8e5d6ab
DOI: 10.1101/643114

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