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Article

Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections.

Cell reports. Medicine - 17 Feb 2026

Snell Luke B, Pickering Suzanne, Alcolea-Medina Adela, Winstone Helena, Seow Jeffrey, Graham Carl, O'Connell Lorcan, Batra Rahul, Malim Michael H, Doores Katie J, Nebbia Gaia, Edgeworth Jonathan D, Neil Stuart J D, Galão Rui P

Abstract excerpt

Evolution of SARS-CoV-2 in long-term persistent infections is hypothesized to be a major source of variants of concern (VOCs). However, linking intra-host variants into haplotypes that reflect viral subpopulations is limited by commonly used genomic sequencing techniques. We develop sequencing and analysis methods for identifying full-length spike haplotypes and analyze their diversification during persistent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 41633357
DOI: 10.1016/j.xcrm.2026.102587
PMCID: PMC12923952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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