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Prevalence of Colorectal Cancer Molecular Profiles Is Not Captured by a Single Age Threshold

2026-08-14

Abstract excerpt

Early- and average-onset colorectal cancer (CRC) are separated at age 50, but whether this defines a biological threshold remains unclear. To clarify this, we identified molecular profiles in nine harmonised cBioPortal CRC cohorts (4,609 patients) by fitting Bernoulli mixture models to 31 repair-state, genomic-burden, and gene-alteration features, excluding age, sex, and tumour site, and compared their prevalence...

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Literature Corpus work
ecc3e6e7-9a51-523d-9cf1-d0f364891d7d
DOI
10.64898/2026.08.13.743895
Open publication

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Prevalence of Colorectal Cancer Molecular Profiles Is Not Captured by a Single Age ThresholdDOI 10.64898/2026.08.13.743895
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