Article
Associations between colorectal cancer molecular markers and pathways with clinicopathologic features in older women.
Gastroenterology - 1 Aug 2013
Samadder N Jewel, Vierkant Robert A, Tillmans Lori S, Wang Alice H, Weisenberger Daniel J, Laird Peter W, Lynch Charles F, Anderson Kristin E, French Amy J, Haile Robert W, Potter John D, Slager Susan L, Smyrk Thomas C, Thibodeau Stephen N, Cerhan James R, Limburg Paul J
Abstract excerpt
BACKGROUND & AIMS: Colorectal tumors have a large degree of molecular heterogeneity. Three integrated pathways of carcinogenesis (ie, traditional, alternate, and serrated) have been proposed, based on specific combinations of microsatellite instability (MSI), CpG island methylator phenotype (CIMP...
Topics
- Aged
- Aged, 80 and over
- Biomarkers
- Carcinoma
- Cohort Studies
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- DNA, Neoplasm
- Epigenesis, Genetic
- Female
- Humans
- Microsatellite Instability