Article

Pan-cancer analysis of patient-specific gene regulatory landscapes identifies recurrent PD-1 pathway dysregulation linked to outcome

2025-10-06

Abstract excerpt

Cancer heterogeneity remains a major challenge to the development of broadly effective therapies. Although gene expression-based stratification has advanced our understanding of molecular subtypes, it often overlooks the regulatory mechanisms driving tumor progression and therapeutic resistance. These mechanisms are governed by gene regulatory networks—complex systems of transcription factors and other regulators...

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Literature Corpus work: ecba0fcc-b6f5-5e26-8de2-bbc4ca7b1e25
DOI: 10.1101/2025.10.03.680219

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