Article

Upfront whole blood transcriptional patterns in patients receiving immune checkpoint inhibitors associate with clinical outcome

2025-06-13

Abstract excerpt

<title>Abstract</title> <p>Whole blood (WB) transcriptomics offers a minimal-invasive method to assess patients’ immune system. This study aimed to identify transcriptional patterns in WB associated with clinical outcomes in patients treated with immune checkpoint inhibitors (ICIs). We performed RNA-sequencing on pre-treatment WB samples from 145 patients with advanced cancer. Additionally, we compiled a separate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e561286f-2222-565f-ba61-e8512d0f743c
DOI: 10.21203/rs.3.rs-6843569/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Upfront whole blood transcriptional patterns in patients receiving immune checkpoint inhibitors associate with clinical outcomeDOI 10.21203/rs.3.rs-6843569/v1Read

Immunogenomic landscape of hematological malignanciesSemantic proximity Read

Systemic CD8+ T cell effector signature predicts prognosis of lung cancer immunotherapySemantic proximity Read

Integrated analysis of single-cell and bulk RNA sequencing data reveals a myeloid cell-related regulon predicting neoadjuvant immunotherapy response across cancersSemantic proximity Read

A transcriptome-wide meta-analysis reveals lack of cancer-cell intrinsic determinants of response to immune checkpoint blockadeSemantic proximity Read

Dissecting the tumor microenvironment in response to immune checkpoint inhibitors via single-cell and spatial transcriptomicsSemantic proximity Read

A Pan-Cancer Immunogenomic Atlas for Immune Checkpoint Blockade ImmunotherapySemantic proximity Read

Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor TherapySemantic proximity Read

Single-cell meta-analysis of T cells reveals clonal dynamics of response to checkpoint immunotherapySemantic proximity Read

Current transcriptome database and biomarker discovery for immunotherapy by immune checkpoint blockadeSemantic proximity Read

Pan‐cancer RNA‐seq data stratifies tumours by some hallmarks of cancerSemantic proximity Read

Clinically oriented prediction of patient response to targeted and immunotherapies from the tumor transcriptomeSemantic proximity Read

Integrated analysis of single-cell and bulk RNA sequencing data reveals a CD8+ T cells signature predicting prognosis and immunotherapy response in hepatocellular carcinomaSemantic proximity Read