Article
Impaired adult hippocampal neurogenesis in a mouse model of familial hypercholesterolemia: A role for the LDL receptor and cholesterol metabolism in adult neural precursor cells.
Molecular metabolism - 1 Dec 2019
Engel Daiane F, Grzyb Anna N, de Oliveira Jade, Pötzsch Alexandra, Walker Tara L, Brocardo Patricia S, Kempermann Gerd, de Bem Andreza F
Abstract excerpt
OBJECTIVE: In familial hypercholesterolemia (FH), mutations in the low-density lipoprotein (LDL) receptor (LDLr) gene result in increased plasma LDL cholesterol. Clinical and preclinical studies have revealed an association between FH and hippocampus-related memory and mood impairment. We here asked whether hippocampal pathology in FH might be a consequence of compromised adult hippocampal neurogenesis. METHODS:...
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