Article

<i>Arap1</i> Loss Causes RPE Phagocytic Dysfunction and Subsequent Photoreceptor Death

2021-08-10

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Arap1 is an Arf-directed GTPase-activating protein (GAP) shown to modulate actin cytoskeletal dynamics by regulating Arf and Rho family members. We have previously shown that Arap1 -/- mice develop photoreceptor degeneration similar to the human condition retinitis pigmentosa (RP), corroborated by fundus examination, histopathology, and ERG analysis. However, Arap1 expressio...

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Literature Corpus work: ecacea4c-236a-5758-ba2c-362b9627fc84
DOI: 10.1101/2021.08.09.455745

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