Article

Loss of ciliary proteins IFT20 and IFT88 results in defective phagocytosis and metabolism in the RPE

2025-10-17

Abstract excerpt

<h4>Summary</h4> A major proportion of retinal disease-causing genes are related to the primary cilium, a microtubule-based signalling organelle essential for multiple developmental pathways. Previous work has shown that the primary cilium plays a crucial role in the development of the retinal pigment epithelium (RPE) affecting homeostasis and function, in particular phagocytosis. We used a cell biology approach...

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Literature Corpus work: 06d61a43-976f-58f6-bbf9-04125b7c2105
DOI: 10.1101/2025.10.16.682843

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