Article

Lysosomal proteolysis of amyloid beta is impeded by fibrils grown in both acidic and neutral pH environments

2021-06-18

Abstract excerpt

Aggregation of amyloid-beta (Aβ) into extracellular plaques is a well-known hallmark of Alzheimer’s disease (AD). Similarly, autophagic vacuoles, autophagosomes, and other residual bodies within dystrophic neurites, though more difficult to detect, are characteristic features of AD. To explore the potential intersection between these observations, we conducted experiments to assess whether Aβ fibril formation disr...

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Literature Corpus work: 47362b24-8383-5c12-b3a4-7e4170b040f6
DOI: 10.1101/2021.06.18.449015

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