Article

STING controls T cell memory fitness during infection through T cell intrinsic and IDO dependent mechanisms

2022-03-20

Abstract excerpt

Stimulator of interferon genes (STING) signaling has been extensively studied in inflammatory diseases and cancer while its role in T cell responses to infection is unclear. Using Listeria monocytogenes strains engineered to induce different levels of c-di-AMP, we found that strong STING signals impaired T cell memory upon infection via increased Bim levels and apoptosis. Unexpectedly, reduction of TCR signal str...

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Identifiers and source

Literature Corpus work: ec937e01-cf27-52a0-ae51-236e6ea820ed
DOI: 10.1101/2022.03.19.484992

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