Article

Induction of the ISR by AB5 subtilase cytotoxin drives type-I IFN expression in pDCs via STING activation

2024-10-12

Abstract excerpt

<h4>SUMMARY</h4> We demonstrate that exposure to the AB5 subtilase cytotoxin (SubAB) induces the unfolded protein response (UPR) in human peripheral blood mononuclear cells, concomitant with a pro-inflammatory response across distinct cell subsets. Notably, SubAB selectively induces type-I interferon (IFN) expression in plasmacytoid dendritic cells, acting synergistically with Toll-like receptor 7 stimulation. Th...

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Literature Corpus work: dff36553-e7f1-54b8-97ec-473c9d997253
DOI: 10.1101/2024.10.07.616986

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