Article

Intermittent Ca <sup>2+</sup> signals mediated by Orai1 regulate basal T cell motility

2017-11-01

Abstract excerpt

Ca 2+ influx through Orai1 channels is crucial for several T cell functions, but a role in regulating basal cellular motility has not been described. Here we show that inhibition of Orai1 channel activity increases average cell velocities by reducing the frequency of pauses in human T cells migrating through confined spaces, even in the absence of extrinsic cell contacts or antigen recognition. Utilizing a novel...

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Identifiers and source

Literature Corpus work: ec89ec52-5327-5669-ac9c-0f7051fbadba
DOI: 10.1101/212274

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