Self-extinguishing relay waves enable homeostatic control of human neutrophil swarming

Abstract excerpt

Neutrophils exhibit self-amplified swarming to sites of injury and infection. How swarming is controlled to ensure the proper level of neutrophil recruitment is unknown. Using an ex vivo model of infection, we find that human neutrophils use active relay to generate multiple pulsatile waves of swarming signals. Unlike classic active relay systems such as action potentials, neutrophil swarming relay waves are self...

Topics

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• Adenylyl Cyclases
• Cell Adhesion Molecules Research
• Models, Biological
• Movement
• Mutation
• Myxococcus xanthus
• Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Time Factors

Identifiers and source

Literature Corpus work

47277a06-7fe0-5dd3-9b72-354e04922ecd

DOI

10.1101/2023.06.27.546744