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Article

Fractional re-distribution among cell motility states during ageing.

Communications biology - 19 Jan 2021

Phillip Jude M, Zamponi Nahuel, Phillip Madonna P, Daya Jena, McGovern Shaun, Williams Wadsworth, Tschudi Katherine, Jayatilaka Hasini, Wu Pei-Hsun, Walston Jeremy, Wirtz Denis

Abstract excerpt

Ageing in humans is associated with the decreased capacity to regulate cell physiology. Cellular properties, such as cell morphology and mechanics, encode ageing information, and can therefore be used as robust biomarkers of ageing. Using a panel of dermal fibroblasts derived from healthy donors spanning a wide age range, we observe an age-associated decrease in cell motility. By taking advantage of the...

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PMID: 33469145
DOI: 10.1038/s42003-020-01605-w
PMCID: PMC7815872

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