Article
Orai1 function is essential for T cell homing to lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013
Greenberg Milton L, Yu Ying, Leverrier Sabrina, Zhang Shenyuan L, Parker Ian, Cahalan Michael D
Abstract excerpt
In T lymphocytes, Ca(2+) release-activated Ca(2+) (CRAC) channels composed of Orai1 subunits trigger Ag-induced gene expression and cell proliferation through the NFAT pathway. We evaluated the requirement of CRAC channel function for lymphocyte homing using expression of a dominant-negative Orai1-E106A mutant to suppress Ca(2+) signaling. To investigate homing and motility of human lymphocytes in...
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