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Article

Single-molecule visualization of human A2A adenosine receptor activation by a G protein and constitutively activating mutations.

Communications biology - 30 Nov 2023

Wei Shushu, Pour Niloofar Gopal, Tiruvadi-Krishnan Sriram, Ray Arka Prabha, Thakur Naveen, Eddy Matthew T, Lamichhane Rajan

Abstract excerpt

Mutations that constitutively activate G protein-coupled receptors (GPCRs), known as constitutively activating mutations (CAMs), modify cell signaling and interfere with drugs, resulting in diseases with limited treatment options. We utilize fluorescence imaging at the single-molecule level to visualize the dynamic process of CAM-mediated activation of the human A2A adenosine receptor (A2AAR) in real time. We...

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Identifiers

PMID: 38036689
DOI: 10.1038/s42003-023-05603-6
PMCID: PMC10689853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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