Sub-Millivolt Voltage Imaging Reveals Gap Junction-Mediated Bioelectric Contact Inhibition

Abstract excerpt

Sub-millivolt membrane potential ( V m ) dynamics in multicellular non-excitable networks have remained largely invisible due to a lack of sufficiently sensitive imaging tools. Here, we introduce rEstus2s, a next-generation genetically encoded voltage indicator that overcomes this barrier by enabling high-resolution V m imaging across the full physiological resting V m range (-100 to 0 mV). Using rEstus2s, we u...

Topics

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• Action Potentials
• Angiotensin-Converting Enzyme 2
• Mice
• Mutation
• Neurons
• Rhodopsin

Identifiers and source

Literature Corpus work

0e367fec-cbf2-503c-a02a-3196621ff3a1

DOI

10.64898/2026.02.10.701308