Article

TCF7L2: a potential key regulator of antidepressant effects on hippocampal astrocytes in depression model mice

2023-08-11

Abstract excerpt

<h4>Aim</h4> Clinical and preclinical studies suggest that hippocampal astrocyte dysfunction is involved in the pathophysiology of depression; however, the underlying molecular mechanisms remain unclear. Here, we attempted to identify the hippocampal astrocytic transcripts associated with antidepressant effects in a mouse model of depression. <h4>Methods</h4> We used a chronic corticosterone-induced mouse model...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec88f0cb-9d2d-5f91-8dcc-95ef9b84ba38
DOI: 10.1101/2023.08.09.552412

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TCF7L2: a potential key regulator of antidepressant effects on hippocampal astrocytes in depression model miceDOI 10.1101/2023.08.09.552412Read

Glucocorticoid receptors mediate reprogramming of astrocytes in depressionSemantic proximity Read

Astrocytic ALKBH5 in stress response contributes to depressive-like behaviors in miceSemantic proximity Read

Sex-Specific Regulation of Stress Susceptibility by the Astrocytic Gene <i>Htra1</i>Semantic proximity Read

Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stressSemantic proximity Read

Assessing the relationships between neurological and psychiatric diseases with astrocyte subtypes and psychotropic medicationsSemantic proximity Read

Stress Induced Transcriptional and Epigenetic Plasticity of Astrocytes, Microglia and Oligodendrocytes in the Pathophysiology of DepressionSemantic proximity Read

A novel two-hit insomnia and inflammation rodent model of depressive-like behaviorsSemantic proximity Read

Electroconvulsive stimuli reverse neuro-inflammation and behavioral deficits in a mouse model of depressionSemantic proximity Read

Glucocorticoid treatment of astrocytes results in temporally dynamic transcriptome regulation and astrocyte-enriched mRNA changes in vitroSemantic proximity Read

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data from the Hippocampus and CortexSemantic proximity Read

Transcription factor activity profiling reveals the role of REST and LEF1 in the recovery from depressionSemantic proximity Read

Multi-omics characterization of astrocyte subtypes reveals spatially coordinated astrocyte downregulation in depressionSemantic proximity Read