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optiPRM: A targeted immunopeptidomics LC-MS workflow with ultra-high sensitivity for the detection of mutation-derived tumor neoepitopes from limited input material

2023-08-23

Abstract excerpt

<h4>ABSTRACT</h4> Personalized cancer immunotherapies such as vaccines and T cell receptor (TCR)-transgenic T cells rely on the presentation of tumor-specific peptides by human leukocyte antigen (HLA) class I molecules to cytotoxic T cells. Such neoepitopes can for example arise from somatic mutations and their identification is crucial for the rational design of new therapeutic interventions. For their detection...

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Literature Corpus work: ec82b85f-a94c-5044-85ca-794718f34a0a
DOI: 10.1101/2023.08.22.554248

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