From prediction to precision: how immunopeptidomics advances neoantigen discovery.

Abstract excerpt

T cell recognition of peptides presented by class I and II human leukocyte antigen (HLA) molecules is fundamental to cancer immunity and personalized immunotherapy. Neoantigens, peptides containing somatic mutations, are attractive therapeutic targets due to their tumor specificity and immunogenicity. Current neoantigen discovery pipelines rely on sequencing and computational predictions but often struggle to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antigen Presentation
• Share to Antigens, Neoplasm
• Share to Immunotherapy