optiPRM: A Targeted Immunopeptidomics LC-MS Workflow With Ultra-High Sensitivity for the Detection of Mutation-Derived Tumor Neoepitopes From Limited Input Material.

doi:10.1016/j.mcpro.2024.100825

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optiPRM: A Targeted Immunopeptidomics LC-MS Workflow With Ultra-High Sensitivity for the Detection of Mutation-Derived Tumor Neoepitopes From Limited Input Material.

Molecular & cellular proteomics : MCP - 1 Sept 2024

Salek Mogjiborahman, Förster Jonas D, Becker Jonas P, Meyer Marten, Charoentong Pornpimol, Lyu Yanhong, Lindner Katharina, Lotsch Catharina, Volkmar Michael, Momburg Frank, Poschke Isabel, Fröhling Stefan, Schmitz Marc, Offringa Rienk, Platten Michael, Jäger Dirk, Zörnig Inka, Riemer Angelika B

Abstract excerpt

Personalized cancer immunotherapies such as therapeutic vaccines and adoptive transfer of T cell receptor-transgenic T cells rely on the presentation of tumor-specific peptides by human leukocyte antigen class I molecules to cytotoxic T cells. Such neoepitopes can for example arise from somatic mutations and their identification is crucial for the rational design of new therapeutic interventions. Liquid...

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PMID: 39111711
DOI: 10.1016/j.mcpro.2024.100825
PMCID: PMC11405902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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