Article

Fibril fragmentation generates diversity in seed population

2024-11-12

Abstract excerpt

Neurodegenerative diseases are characterised by the formation and accumulation of protein fibrils. The mechanism underlaying this aggregation process remains poorly understood. Fibril fragmentation, resulting in seed generation, plays a role in toxicity. Here we provide a quantitative picture of the impact of ultrasound on patient-derived and recombinant fibrils from various diseases. Fragmentation of recombinant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec63f8ab-6f76-5cdf-9020-7d4057ce34fc
DOI: 10.1101/2024.11.12.623277

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fibril fragmentation generates diversity in seed populationDOI 10.1101/2024.11.12.623277Read

Protein transmission in neurodegenerative disease.Semantic proximity Read

Passaging Human Tauopathy Patient Samples in Cells Generates Heterogeneous Fibrils with a Subpopulation Adopting Disease FoldsSemantic proximity Read

Fracture and Growth Are Competing Forces Determining the Fate of Conformers in Tau Fibril Populations.Semantic proximity Read

Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis.Semantic proximity Read

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein PathologySemantic proximity Read

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like SpreadingSemantic proximity Read

Sonicated fibrils of huntingtin exon-1 preferentially seed neurons and produce toxic assembliesSemantic proximity Read

FibrilPaint: a class of amyloid-targeting peptidesSemantic proximity Read

Direct evidence for self-propagation of different amyloid-β fibril conformations.Semantic proximity Read

Sound-mediated nucleation and growth of amyloid fibrilsSemantic proximity Read

Zinc Differentially Modulates Tau Aggregation, Fibril Morphology, and Prion-like Seeding in a Construct-Dependent MannerSemantic proximity Read

FibrilPaints for visualisation and ubiquitination of Huntingtin amyloid fibrilsSemantic proximity Read