Article
Protein transmission in neurodegenerative disease.
Nature reviews. Neurology - 1 Apr 2020
Peng Chao, Trojanowski John Q, Lee Virginia M-Y
Abstract excerpt
Most neurodegenerative diseases are characterized by the intracellular or extracellular aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α-synuclein in Parkinson disease, and TAR DNA-binding protein 43 in amyotrophic lateral sclerosis. Accumulating evidence from both human studies and disease models indicates that intercellular transmission and the subsequent templated...
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