Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8 + T Cells Responding to Coronavirus Infection

doi:10.1111/acel.70109

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Article

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8 + T Cells Responding to Coronavirus Infection

21 May 2025

Abstract excerpt

ABSTRACT T cell aging increases the risk of viral infection‐related morbidity and mortality and reduces vaccine efficacy in the elderly. A major hallmark of T cell aging is the loss of quiescence and shift toward terminal differentiation during homeostasis. However, how aging impacts the differentiation program of virus‐specific T cells during infection is unclear. Here, in a murine coronavirus (MHV) infection...

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PMID: 40396260
DOI: 10.1111/acel.70109

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