Article

Dynamic Loading of Human Engineered Heart Tissue Enhances Contractile Function and Drives Desmosome-linked Disease Phenotype

2020-05-27

Abstract excerpt

<h4>ABSTRACT</h4> The role mechanical forces play in shaping the structure and function of the heart is critical to understanding heart formation and the etiology of disease but is challenging to study in patients. Engineered heart tissues (EHTs) incorporating human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes have the potential to provide insight into these adaptive and maladaptive changes in the...

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Literature Corpus work: ec1fd673-2608-5af9-8600-10150f7fb62e
DOI: 10.1101/2020.05.25.111690

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