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Article

Dynamic loading of human engineered heart tissue enhances contractile function and drives a desmosome-linked disease phenotype.

Science translational medicine - 21 Jul 2021

Bliley Jacqueline M, Vermeer Mathilde C S C, Duffy Rebecca M, Batalov Ivan, Kramer Duco, Tashman Joshua W, Shiwarski Daniel J, Lee Andrew, Teplenin Alexander S, Volkers Linda, Coffin Brian, Hoes Martijn F, Kalmykov Anna, Palchesko Rachelle N, Sun Yan, Jongbloed Jan D H, Bomer Nils, de Boer Rudolf A, Suurmeijer Albert J H, Pijnappels Daniel A, Bolling Maria C, van der Meer Peter, Feinberg Adam W

Abstract excerpt

The role that mechanical forces play in shaping the structure and function of the heart is critical to understanding heart formation and the etiology of disease but is challenging to study in patients. Engineered heart tissues (EHTs) incorporating human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes have the potential to provide insight into these adaptive and maladaptive changes. However, most EHT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34290054
DOI: 10.1126/scitranslmed.abd1817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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