Article

Desmoplakin loss leads to PKC-dependent insertion of series sarcomeres and contractile dysfunction in cardiomyocytes

2025-05-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mutations in DSP , which encodes the protein desmoplakin, lead to cardiomyopathy with unusually high penetrance. Clinical features include ventricular tachyarrhythmias, fibro-fatty infiltration of both ventricles, and ultimately dilated cardiomyopathy. While some data have been gathered to explain the electrophysiological and contractile consequences of desmoplakin cardiomy...

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Literature Corpus work: 5a7b62c6-3634-58f6-babc-d51b48568e58
DOI: 10.1101/2025.05.15.654389

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