Article
Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.
Human molecular genetics - 15 Oct 2009
Smith Ruben, Bacos Karl, Fedele Valentina, Soulet Denis, Walz Helena A, Obermüller Stefanie, Lindqvist Anders, Björkqvist Maria, Klein Pontus, Onnerfjord Patrik, Brundin Patrik, Mulder Hindrik, Li Jia-Yi
Abstract excerpt
Huntington's disease is a severe progressive neurodegenerative disorder caused by a CAG expansion in the IT15 gene, which encodes huntingtin. The disease primarily affects the neostriatum and cerebral cortex and also associates with increased incidence of diabetes. Here, we show that mutant huntingtin disrupts intracellular transport and insulin secretion by direct interference with microtubular beta-tubulin. We...
Topics
- Animals
- Cell Line, Tumor
- Disease Models, Animal
- Humans
- Huntingtin Protein
- Huntington Disease
- Insulin
- Insulin-Secreting Cells
- Mice
- Mice, Transgenic