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Article

Thiopurines activate an antiviral unfolded protein response that blocks viral glycoprotein accumulation in cell culture infection model

2020-10-01

Abstract excerpt

<h4>ABSTRACT</h4> Enveloped viruses, including influenza A viruses (IAVs) and coronaviruses (CoVs), utilize the host cell secretory pathway to synthesize viral glycoproteins and direct them to sites of assembly. Using an image-based high-content screen, we identified two thiopurines, 6-thioguanine (6-TG) and 6-thioguanosine (6-TGo), that selectively disrupted the processing and accumulation of IAV glycoproteins h...

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Identifiers and source

Literature Corpus work
ebf5ddc7-f9a6-5640-bfc8-1f86184c820e
DOI
10.1101/2020.09.30.319863
Open publication

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Thiopurines activate an antiviral unfolded protein response that blocks viral glycoprotein accumulation in cell culture infection modelDOI 10.1101/2020.09.30.319863
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