Article

Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation

2022-05-02

Abstract excerpt

Stress granules (SGs) are cytoplasmic condensates that often form as part of the cellular antiviral response. Despite the growing interest in understanding the interplay between SGs and other biological condensates and viral replication, the role of SG formation during coronavirus infection remains poorly understood. Several proteins from different coronaviruses have been shown to suppress SG formation upon overex...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a3021aa0-4295-5b23-95a0-62e249a36909
DOI: 10.1101/2022.05.02.490272

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formationDOI 10.1101/2022.05.02.490272Read

Inhibition of Stress Granule Formation by Middle East Respiratory Syndrome Coronavirus 4a Accessory Protein Facilitates Viral Translation, Leading to Efficient Virus ReplicationSemantic proximity Read

Antagonism of stress granules key for SARS-CoV-2 infection and pathogenesisSemantic proximity Read

The nucleocapsid (N) proteins of different human coronaviruses demonstrate a variable capacity to induce the formation of cytoplasmic condensatesSemantic proximity Read

Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral InclusionsSemantic proximity Read

Stress Granule Components G3BP1 and G3BP2 Play a Proviral Role Early in Chikungunya Virus ReplicationSemantic proximity Read

SARS-CoV-2 Nucleocapsid protein attenuates stress granule formation and alters gene expression via direct interaction with host mRNAsSemantic proximity Read

SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replicationSemantic proximity Read

Alphavirus-induced transcriptional and translational shutoffs play major roles in blocking the formation of stress granulesSemantic proximity Read

Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses.Semantic proximity Read

Feline Calicivirus Infection Disrupts Assembly of Cytoplasmic Stress Granules and Induces G3BP1 CleavageSemantic proximity Read

Mammalian Orthoreovirus Factories Modulate Stress Granule Protein Localization by Interaction with G3BP1Semantic proximity Read

Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinerySemantic proximity Read