Article

HPV16 E7 Nucleotide Variants Found in Cancer-Free Subjects Affect E7 Protein Expression and Transformation

2021-11-08

Abstract excerpt

The human papillomavirus (HPV) type 16 E7 oncogene is critical to carcinogenesis and highly conserved. Previous studies identified a preponderance of non-synonymous E7 variants amongst HPV16-positive cancer-free controls compared to those with cervical cancer. To investigate the function of E7 variants, we constructed full-length HPV16 E7 genes and tested variants at positions H9R, D21N, N29S, E33K, T56I, D62N, S6...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ebf0fc63-a96a-5a25-8eb4-0b7d389e165d
DOI: 10.20944/preprints202111.0134.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HPV16 E7 Nucleotide Variants Found in Cancer-Free Subjects Affect E7 Protein Expression and TransformationDOI 10.20944/preprints202111.0134.v1Read

HPV16 E7 Nucleotide Variants Found in Cancer-Free Subjects Affect E7 Protein Expression and TransformationSemantic proximity Read

HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis.Semantic proximity Read

HPV16 E7 oncogene expression in normal human epithelial cells causes molecular changes indicative of an epithelial to mesenchymal transitionSemantic proximity Read

Characterization of patient-derived HPV16 E6 and E7 variant alleles.Semantic proximity Read

The human papillomavirus 16 European-T350G E6 variant can immortalize but not transform keratinocytes in the absence of E7.Semantic proximity Read

Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control.Semantic proximity Read

Enhanced oncogenicity of Asian-American human papillomavirus 16 is associated with impaired E2 repression of E6/E7 oncogene transcriptionSemantic proximity Read

Phylogenetic and functional analysis of sequence variation of human papillomavirus type 31 E6 and E7 oncoproteins.Semantic proximity Read

Sequence analysis of the long control region of human papillomavirus type 16 variants and functional consequences for P97 promoter activitySemantic proximity Read

The E8 Domain Confers a Novel Long-Distance Transcriptional Repression Activity on the E8^E2C Protein of High-Risk Human Papillomavirus Type 31Semantic proximity Read

Ubiquitous presence of E6 and E7 transcripts in human papillomavirus?Positive cervical carcinomas regardless of its typeSemantic proximity Read

Sequence variation of human papillomavirus type 16 E7 in preinvasive and invasive cervical neoplasias.Semantic proximity Read