HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis.

doi:10.1016/j.cell.2017.08.001

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Article

HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis.

Cell - 7 Sept 2017

Mirabello Lisa, Yeager Meredith, Yu Kai, Clifford Gary M, Xiao Yanzi, Zhu Bin, Cullen Michael, Boland Joseph F, Wentzensen Nicolas, Nelson Chase W, Raine-Bennett Tina, Chen Zigui, Bass Sara, Song Lei, Yang Qi, Steinberg Mia, Burdett Laurie, Dean Michael, Roberson David, Mitchell Jason, Lorey Thomas, Franceschi Silvia, Castle Philip E, Walker Joan, Zuna Rosemary, Kreimer Aimée R, Beachler Daniel C, Hildesheim Allan, Gonzalez Paula, Porras Carolina, Burk Robert D, Schiffman Mark

Abstract excerpt

Although most cervical human papillomavirus type 16 (HPV16) infections become undetectable within 1-2 years, persistent HPV16 causes half of all cervical cancers. We used a novel HPV whole-genome sequencing technique to evaluate an exceptionally large collection of 5,570 HPV16-infected case-control samples to determine whether viral genetic variation influences risk of cervical precancer and cancer. We observed...

Topics

Adult
Alphapapillomavirus
Carcinoma
Case-Control Studies
Female
Genome, Viral
Humans
Middle Aged
Papillomavirus E7 Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Papillomavirus Infections

Polymorphism, Single Nucleotide

Uterine Cervical Neoplasms

Young Adult

Source

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Identifiers

PMID: 28886384
DOI: 10.1016/j.cell.2017.08.001
PMCID: PMC5674785

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